Name：Jun-Jun He
Professional title：Associate Researcher
Research focus：Veterinary
Tutor category：£PhD Supervisor þMaster Supervisor £Neither
E-mail address：
hejunjun617@163.com
Education
2012.9－2016.7, Graduate School of Chinese Academy of Agricultural Sciences，PhD
2008.9－2011.7, Guangxi Universit, Master
2003.9－2007.7, Guangxi University, Bachelor
Career
2023.10－, Yunnan Agricultural University, Associate Researcher
2022.01－2023.10, Yunnan Agricultural University, Research assistant
2016.07－2021.12, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Research assistant
Courses
Veterinary parasitology
Research focus
1. Parasitic zoonosis
2. Veterinary Public Health
Research & Teaching
Research projects
1. National Natural Science Foundation－Regional Foundation Project, Grant No. 32460890, The mechanism study of host inflammatory responses enhanced by Toxoplasma gondii PPM3H protein phosphatase，2025.01-2028.12，0.32 million, in charge
2. Yunnan International Science and Technology Correspondent (Individual) 2024，Grant No. 202403AK140020. 2024.09-2026.08, 0.10 million, in charge
3. National Natural Science Foundation－Youth Science Foundation Project, Grant No.31902291, Study the role of PPM3H in Toxoplasma gondii virulence and its biologcial functions, 2020.01-2022.12, 0.25 million, in charge
4. Science and Technology Department of Gansu Province－Youth Science and technology Fund program, Grant No.20JR5RA581, Identification of sexual reproductive genes of Toxoplasma gondii that co-expressed with the genes of small intestinal epithelial cells of cats, 2020.11-2022.10, 0.03 million, in charge
5. Science and Technology Department of Yunnan Province, "Three Districts" Science and technology Talents support program, 2014.09-2024.08, 0.02 million, in charge.
Representative achievements
Journal Publications
1. Meng-Ling Deng#, Jun-Rong Chen#, Jian-Fa Yang, Jun Ma, Fan-Fan Shu, Feng-Cai Zou*, Jun-Jun He*. (2024). Transcriptomic analysis of reproductive organs of pregnant mice post Toxoplasma gondii infection reveals the potential factors that contribute to poor prognosis. Front Microbiol. 15:1431183.
2. Bintao Zhai, Shi-Chen Xie, Jiyu Zhang, Jun-Jun He*, Xing-Quan Zhu*. (2023). Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection. Infectious diseases of poverty, 12(1), 68.
3. Jian-Fa Yang, Zhao-Jun Heng, Fan-Fan Shu, Hua-Ming Mao, Yong-Sheng Su, Jun-Jun He*, Feng-Cai Zou*. (2023). Molecular Epidemiological Investigation of Cyclospora spp. in Holstein Cattle in Partial Areas of the Yunnan Province, China. Animals, 13(9), 1527.
4. Hai-Yang Song#, Meng-Ling Deng#, Jian-Fa Yang, Jun Ma, Fan-Fan Shu, Wen-Jie Cheng, Xing-Quan Zhu, Feng-Cai Zou*, Jun-Jun He*. (2023). Transcriptomic, 16S ribosomal ribonucleic acid and network pharmacology analyses shed light on the anticoccidial mechanism of green tea polyphenols against Eimeria tenella infection in Wuliangshan black-boned chickens. Parasites & vectors, 16(1), 330.
5. Zhao Li*, Xiao-Xia Ren, Yin-Jiao Zhao, Lian-Tao Yang, Bo-Fang Duan, Na-Ying Hu, Feng-Cai Zou, Xing-Quan Zhu, Jun-Jun He*, Qi-Shuai Liu*. (2022). First report of haemosporidia and associated risk factors in red junglefowl (Gallus gallus) in China. Parasites & vectors, 15(1), 275.
6. Zhao-Jun Heng, Jian-Fa Yang, Xin-Yan Xie, Cui-Rong Xu, Jun-Rong Chen, Jun Ma, Jun-Jun He*, Hua-Ming Mao*. (2022). Prevalence and multilocus genotyping of Giardia duodenalis in Holstein cattle in Yunnan, China. Frontiers in veterinary science, 9, 949462.
7. Xiao-Hui Hu, Shi-Chen Xie, Qin-Li Liang, Li-Xiu Sun, Zhao Li, Jian-Fa Yang, Xing-Quan Zhu, Feng-Cai Zou*, Jun-Jun He*. (2022). Seroprevalence and risk factors of Toxoplasma gondii and Neospora caninum infection in black goats in Yunnan Province, Southwestern China. Frontiers in veterinary science, 9, 975238.
8. Bintao Zhai, Shichen Xie, Junjie Peng, Yanhua Qiu, Yang Liu, Xingquan Zhu, Junjun He*, Jiyu Zhang*.(2022). Glycosylation Analysis of Feline Small Intestine Following Toxoplasma gondii Infection. Animals, 12(20), 2858.
9. Ying-Wen Meng#, Fan-Fan Shu#, Li-Hua Pu, Yang Zou, Jian-Fa Yang, Feng-Cai Zou, Xing-Quan Zhu, Zhao Li*, Jun-Jun He*. Occurrence and molecular characterization of Cryptosporidium spp. in dairy cattle and dairy buffalo in Yunnan Province, Southwest China. Animals, 2022, 12(8):1031.
10. Hai-Yang Song, Kai-Sheng Wang, Jian-Fa Yang, Hua-Ming Mao, Li-Hua Pu, Yang Zou, Jun Ma, Xing-Quan Zhu, Feng-Cai Zou*, Jun-Jun He*. Prevalence and novel genotypes identification of Enterocytozoon bieneusi in dairy cattle in Yunnan Province, China. Animals, 2021, 11(11):3014.
11. Jun-Jun He, Jun Ma, Jin-Lei Wang, Fu-Kai Zhang, Jie-Xi Li, Bin-Tao Zhai, Ze-Xiang Wang, Hany M Elsheikha*, Xing-Quan Zhu*. Global transcriptome profiling of multiple porcine organs reveals Toxoplasma gondii-induced transcriptional landscapes. Front Immunol, 2019, 10:1531.
12. Rui-Si Hu, Jun-Jun He*, Hany M Elsheikha, Yang Zou, Muhammad Ehsan, Qiao-Ni Ma, Xing-Quan Zhu, Wei Cong*. Transcriptomic profiling of mouse brain during acute and chronic infections by Toxoplasma gondii oocysts. Front Microbiol, 2020, 11:570903.
13. Jun Ma, Jun-Jun He*, Jun-Ling Hou, Chun-Xue Zhou, Hany M. Elsheikha*, Xing-Quan Zhu. Ultra performance liquid chromatography-tandem mass spectrometry-based metabolomics reveals metabolic alterations in the mouse cerebellum during Toxoplasma gondii infection. Front Microbiol, 2020, 11:1555.
14. Wei Shi, Jun-Jun He*, Xue-Fang Mei, Ke-Jing Lu, Zi-Xuan Zeng, Yao-Yao Zhang, Zhao-An Sheng, Hany M Elsheikha, Wei-Yi Huang, Xing-Quan Zhu. Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica. PLoS Negl Trop Dis, 2020, 14(12):e0008951.
15. Jie-Xi Li, Jun-Jun He*, Hany M Elsheikha, Jun Ma, Xiao-Pei Xu, Xing-Quan Zhu. ROP18-mediated transcriptional reprogramming of HEK293T cell reveals new roles of ROP18 in the interplay between Toxoplasma gondii and the host cell. Front Cell Infect Microbiol, 2020, 10:586946.
16. Yan Yang#, Jun-Jun He#, Shuang Hu, Hua Chang, Xun Xiang, Jian-Fa Yang*, Feng-Cai Zou*. Comparative study of transcriptome profiles of mouse livers and skins infected by fork-tailed or non-fork-tailed Schistosoma japonicum. Front Microbiol，2017, 8:1648.
17. Fu-Kai Zhang, Rui-Si Hu, Hany M Elsheikha, Zhao-An Sheng, Wei-Yu Zhang, Wen-Bin Zheng, Xing-Quan Zhu*, Jun-Jun He*. Global serum proteomic changes in water buffaloes infected with Fasciola gigantica. Parasit Vectors，2019, 12(1):281.
18. Wen-Bin Zheng, Yang Zou, Jun-Jun He*, Guo-Hua Liu, Min-Hua Hu, Xing-Quan Zhu*. Proteomic alterations in the plasma of Beagle dogs induced by Toxocara canis infection. J Proteomics, 2021, 232:104049.
19. Wen-Bin Zheng, Yang Zou, Jun-Jun He*, Hany M Elsheikha, Guo-Hua Liu, Min-Hua Hu, Shui-Lian Wang, Xing-Quan Zhu*. Global profiling of lncRNAs-miRNAs-mRNAs reveals differential expression of coding genes and non-coding RNAs in the lung of beagle dogs at different stages of Toxocara canis infection. Int J Parasitol, 2021, 51(1):49-61.
20. Jun-Jun He#, Jun Ma#, Jin-Lei Wang, Fu-Kai Zhang, Jie-Xi Li, Bin-Tao Zhai, Hany M Elsheikha*, Xing-Quan Zhu*. iTRAQ-based quantitative proteomics analysis identifies host pathways modulated during Toxoplasma gondii infection in swine. Microorganisms, 2020, 8(4):518.
21. Jun-Jun He, Jun Ma, Hany M Elsheikha, Hui-Qun Song, Si-Yang Huang*, Xing-Quan Zhu*. Transcriptomic analysis of mouse liver reveals a potential hepato-enteric pathogenic mechanism in acute Toxoplasma gondii infection. Parasit Vectors, 2016, 9(1):427.
22. Meng Wang, Fu-Kai Zhang, Hany M Elsheikha, Nian-Zhang Zhang, Jun-Jun He*, Jian-Xun Luo, Xing-Quan Zhu*. Transcriptomic insights into the early host-pathogen interaction of cat intestine with Toxoplasma gondii. Parasit Vectors，2018, 11(1):592.
23. Qing Liu, Wen-Wei Gao, Hany M Elsheikha, Jun-Jun He*, Fa-Cai Li, Wen-Bin Yang, Xing-Quan Zhu. Transcriptomic analysis reveals Toxoplasma gondii strain-specific differences in host cell response to dense granule protein GRA15. Parasitol Res, 2018, 117(9):2785-2793.
24. Yu-Meng Meng, Bin-Tao Zhai, Hany M Elsheikha, Shi-Chen Xie, Ze-Xiang Wang, Quan Zhao, Xing-Quan Zhu*, Jun-Jun He*. Acetylome analysis of the feline small intestine following Toxoplasma gondii infection. Parasitol Res, 2020, 119(11):3649-3657.
25. Jun-Jun He, Jun Ma, Fa-Cai Li, Hui-Qun Song, Min-Jun Xu*, Xing-Quan Zhu*. Transcriptional changes of mouse splenocyte organelle components following acute infection with Toxoplasma gondii. Exp Parasitol, 2016, 167:7-16.
26. Jun-Jun He, Jun Ma, Jin-Lei Wang, Min-Jun Xu*, Xing-Quan Zhu*. Analysis of miRNA expression profiling in mouse spleen affected by acute Toxoplasma gondii infection. Infect Genet Evol, 2016, 37:137-42.
27. Jun-Jun He, Jun Ma, Hany M Elsheikha, Hui-Qun Song, Dong-Hui Zhou, Xing-Quan Zhu. Proteomic profiling of mouse liver following acute Toxoplasma gondii infection. 2016, PLoS One, 11(3):e0152022.
28. Jun-Jun He, Jun Ma, Hui-Qun Song, Dong-Hui Zhou, Jin-Lei Wang, Si-Yang Huang*, Xing-Quan Zhu*. Transcriptomic analysis of global changes in cytokine expression in mouse spleens following acute Toxoplasma gondii infection. Parasitol Res, 2016, 115(2):703-12.