Name：Xiaobing Li
Professional title：Dr., Professor
Research focus：
1. Nutritional & metabolic diseases and toxonosis of ruminants
2. Veterinary imaging diagnostic technique
Tutor category： ☑PhD Supervisor ☑Master Supervisor
E-mail address：xbli@ynau.edu.cn
Education
1991.09 - 1996.07, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Bachelor.
1996.09 - 1999.07, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Master.
2001.09 - 2005.07, Jilin University, College of Veterinary Medicine, Ph.D.
Career
Jul 1999-Jul 2001, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Teaching Assistant.
Jul 2001-Sep 2008, Changchun Agricultural and Animal Husbandry University, College of Veterinary Medicine, Lecturer.
Sep 2008-Oct 2011, Jilin University, College of Veterinay Medicine, Associate Professor.
Oct 2011-Jan 2020, Jilin University, College of Veterinay Medicine, Professor.
Jan 2020-now, Yunnan Agricultural University, College of Veterinary Medicine, Professor.
Courses
1. Veterinary Clinical Diagnosis
2. Veterinary Imaging
3. Animal Nutritional and Metabolic Diseases
Research & Teaching
Research projects
1. National Natural Science Foundation of China, Regional Science Foundation Project, 32360904, The role and mechanism of bta-miR-27b in liver injury of dairy cows with fatty liver by targeting Nrf2 to regulate pyroptosis, from 2024-01 to 2027-12, 320 thousands, under research, in charge.
2. Science and Technology Department of Yunnan Province, Basic Research Special Project - key project, 202101AS070296, Study on the Mechanism of IFN-τ regulating the Inflammatory injury of endometrial epithelial cells of Dairy Cows through bta-miR-200b/PI3K/ AKT signaling axis, 2022-06 to 2025-05, 500 thousands, under research, in charge.
3. National Natural Science Foundation of China, Regional Science Foundation Project, 32060818, The regulatory role of Nrf2 in the lipid metabolism disorder in the adipose tissue of dairy cows with ketosis, from 2021-01 to 2024-12, 350 thousands, finished, in charge.
4. National Natural Science Foundation of China, general project, 31872536, Regulatory mechanism of Perilipin1 on lipid homeostasis and inflammatory pathway in adipose tissue of ketotic dairy cows, from 2019-01 to 2022-12, 590 thousands, finished, in charge.
5. National Natural Science Foundation of China, general project, 31572581,The effects of high-level NEFA on the lipid metabolism and secretion of adipose tissue in perinatal dairy cows, from 2016-01 to 2019-12, 640 thousands, finished, in charge.
6. National Natural Science Foundation of China, general project, 31272621, AMPK signal transmission mechanism of lipid metabolic disorder in liver of dairy cows with ketosis, from 2013-01 to 2016-12, 810 thousands, finished, in charge.
7. National Natural Science Foundation of China, general project, 30972224, Effect of PTEN and SREBP-1c Gene Regulation on Fatty Deposition in Hepatocyte of Dairy Cows, from 2010-01 to 2012-12, 310 thousands, finished, in charge.
8. National Natural Science Foundation of China, Special Fund Projects, 30640049, Apolipoprotein B100 and E Mechanism of Action on Dairy Cows Fatty Liver Development, from 2007-01 to 2007-12,100 thousands, finished, in charge.
9. Ministry of Science and Technology of the People’s Republic of China, Grants from National Key R&D Program of China, 2016YFD0501007-8, Research on imaging diagnostic technology and prevention & control products of liver and gallbladder diseases in dogs and cats, from 2016.07 to 2020.12, 770 thousands, finished, in charge.
10. Ministry of Science and Technology of the People’s Republic of China, The National High Technology Research and Development Program of China (863 project), 2007AA10Z426, Development of rapid immunological detection technology for four mycotoxins in agricultural products, from 2007-01 to 2010-10, 500 thousands, finished, in charge.
Teaching projects
1. Yunnan Provincial Professional Degree Graduate Teaching Case Library Construction Project, Veterinary Imaging Diagnosis New Technology Case Library, 2023.10-2025.10, under research, in charge.
Awards & Honors
1. Li Xiaobing (3/6) Molecular mechanism of liver injury caused by hepatic lipid metabolism disorder in dairy cows with ketosis，Science and Technology Department of Jilin Province, First prize of Science and Technology Award of Jilin Province, 2020 (Liu Guowen, Li Xinwei, Li Xiaobing, Wang Zhe, Du Xiliang, Song Yuxiang).
2. Li Xiaobing (3/8) Mechanism of high-level NEFA and BHBA on liver lipotoxicity of Ketosis Dairy cows, Science and Technology Department of Jilin Province，Jilin Province natural science academic achievement Award second prize, 2015（Liu Guowen, Li Xinwei, Li Xiaobing, Wang Zhe, Wang Jianguo, Liu Lei, Li Yu, Den Qinghua）.
3. Li Xiaobing (3/15) Molecular mechanism and prevention of ketosis in dairy cows，Science and Technology Department of Jilin Province，First prize of Science and technology progress of Jilin Province, 2010 (Wang Zhe, Liu Guowen, Li Xiaobing, Xv Chuang, Zhang Zhigang, Zhang Naisheng, Chen Chengzhen, Li Yangfei, Xia Cheng, Zhang Cai, Zhang Hui, Yang Wenyan, Niu Shuling, Zhang Yonghong, Xie Guanghong).
Representative achievements
Journal Publications
[1] Kangfeng Jiang#, Yajing Chen#, Kui Wang, Liangyu Yang, Shumin Sun, Jing Yang*, Xiaobing Li*. miR-331-depleted exosomes derived from injured endometrial epithelial cells promote macrophage activation during endometritis[J]. International Journal of Biological Macromolecules. 2024 Nov;279(Pt 4):134967. doi: 10.1016/j.ijbiomac.2024.134967.
[2] Xinyi Fan#, Jie Xu, Yuan Hu, Kui Wang, Yiyi Zhao, Jinyin Cai, Xinyuan Zhang, Binghai Pan, Anqi Xu, Yajing Chen, Songhao Liu, Kangfeng Jiang*, Xiaobing Li*. Effect of high NEFA concentration on lipid metabolism disorders in hepatocytes based on lipidomics[J]. Frontiers in Pharmacology. 2024 Feb 28:15:1372296. doi: 10.3389/fphar.2024.1372296.
[3] Xinwei Li#, Yu Li#, Wentao Yang, Chong Xiao, Shixin Fu, Qinghua Deng, Hongyan Ding, Zhe Wang, Guowen Liu*, Xiaobing Li*. SREBP-1c overexpression induces triglycerides accumulation throughincreasing lipid synthesis and decreasing lipid oxidation and VLDLassembly in bovine hepatocytes[J]. Journal of Steroid Biochemistry & Molecular Biology. 2014, 143: 174-182.
[4] Qinghua Deng# , Xinwei Li# , Shixin Fu, Liheng Yin, Yuming Zhang, Tingting Wang, Jianguo Wang, Lei Liu, Xu Yuan, Guoquan Sun, Zhe Wang, Guowen Liu*, Xiaobing Li*. SREBP-1c Gene Silencing can Decrease Lipid Deposits in Bovine Hepatocytes Cultured in Vitro[J]. Cell Physiol Biochem. 2014; 33(5): 1568-1578.
[5] Xiao-Bing Li#, Wei Yang#, Yi Zhang#, Zhi-Gang Zhang, Tao Kong, Dong-Na Li, Jia-Jia Tang, Lei Liu, Guo-Wen Liu and Zhe Wang*. Preparation and Identification of Monoclonal Antibody against Abrin-a[J]. J Agric Food Chem. 2011, 59(18):9796-9799.
Published books
1. Zhou Zhenlei, Veterinary Diagnostic Imaging. Science Press, 2023 (Co-editor).
2. Deng Ganzhen, CT and MRI Atlas of Small Animals, Liaoning Science and Technology Press, 2021. (Vice-Principal Translator)
3. Wang Zhe and Jiang Yufu, Veterinary Diagnostics, Science Press, 2010. (Associate Editor-in-Chief)
4. Xie Fuqiang, Veterinary Imaging (1st, 2nd, 3rd Edition), China Agricultural University Press, 2004, 2011, 2018. (Co-editor)
5. Deng Ganzhen, Clinical Diagnostics of Veterinary Medicine (1st and 2nd Editions), Higher Education Press, 2009, 2017. (Co-editor)
6. Zhang Zhongqiu and Ding Boliang, Moke Veterinary Handbook, China Agriculture Press, 2015. (Co-editor))
7. Xie Fuqiang, Veterinary Imaging, China Agricultural University Press, 2011. (Co-editor)
8. Zhang Naisheng and Li Yuyi, General Animal Diseases, China Agriculture Press, 2011. (Co-editor)
Patents
1. Li Xiaobing, Li Sunhuo, Bai Hongxu et al., Abdominal ultrasound exercise model and its pathological model, 2021-8-3, China, ZL 201910466629.8.
2. Li Xiaobing, Liu Guowen, Yang Wei et al., One invention relates to colloidal gold immuno-chromatographic test strip of silver dye enhancement technology and a preparation method, 2013-9-4, China, ZL 201010565942.6.
3. Li Xiaobing, Ouyang Huilin, Li Sunhuo et al., A restraint device for radiography of animals, 2020-11-10, China, ZL 202020076103.7.
4. Li Xiaobing, Ouyang Huilin, Li Sunhuo et al., A echocardiography restraint bed for animals, 2020-9-16, China, ZL 201921888618.0.
5. Li Xiaobing, Li Sunhuo, Ouyang Huilin et al., A cassette holder for horizontal X-ray radiography in animals. 2019-8-23, China, ZL 201821640350.4.
Words for students
Academics are specialized because of diligence and wasted because of fun; Virtue is achieved by independent thinking, and corrupted by conformity.