Name：Xiaolong Gu
Professional title：Associated Professor
Tutor category：£PhD Supervisor RMaster Supervisor £Neither
E-mail address：xuewu24588@126.com
Education
2016.10-2018.02, Lebniz Research Center for Working Environment and Human Factors in Germany, Visiting scientist
2013.09-2018.06, China Agricultural University, majoring in Clinical Veterinary Medicine, PhD candidate
2010.09-2013.06, College of Animal Science and Technology, Jiangxi Agricultural University, majoring Clinical Veterinary Medicine, Master of Agriculture
2006.09-2010.06, College of Biological Science and Engineering, Jiangxi Agricultural University, majoring Bioengineering, Bachelor of Engineering
Career
2021.10-now, Postdoctoral scientific research working station of Animal Husbandry, Yunnan Agricultural University Postdoctor
2020.09-now, College of Veterinary Medicine, Yunnan Agricultural University Associated Professor (exceptional promotion)
2019.07-2021.05, Mushu Village,Qianchang Town,Yao'an County,Chuxiong Prefecture Village-Resident-Team
2018.09-2020.09, College of Veterinary Medicine, Yunnan Agricultural University No Grading
Courses
1. Veterinary Clinical Diagnostics
2. Veterinary Internal Medicine
3. Veterinary Professional English
4. Animal Welfare
Research focus
1. Animal Nutrition Metabolism and Poisoning Diseases
2. Liver Pharmacology and Toxicology
Research & Teaching
Research projects
National Natural Science Foundation of China,Youth Project, NO. 31902335, The role of PP2A-Akt/Beclin 1 signaling pathway in α-amanitin-induced autophagy in hepatocytes, 2020.01-2022.12, 240, 000 RMB, Under Research, Preside Over
Science and Technology Agency of Yunnan Province, Fundamental Research Project, Youth Project, NO. 202001AU070097, The role of Nrf2/HO-1 signaling pathway in cadmium-induced renal cell pyroptosis in mice,2020.10-2023.09, 50,000 RMB, Under Research, Preside Over
National Natural Science Foundation of China,National Key R&D Program,NO. 2016YFD0501203,Sub-project of research on the role of trace elements and vitamins in the prevention and control of dairy cow mastitis:Research on prevention and control technology of trace elements,vitamins and electrolyte imbalance in cattle and sheep, 2016.07-2020.10,675,000 RMB,Completed,Participation
Awards & Honors
Gu Xiaolong,Outstanding Member of Chinese Communist Party in Colleges and Universities in Yunnan Province, Education Agency of Yunnan Province, 2020
Gu Xiaolong,Young Talents of “Thousand Talents Program”,Agency of Human Resources and Social Security of Yunnan Province, 2019
Representative achievements
Journal Publications
[1] Xiaolong Gu, Limei Zhang, Weixing Sun, Kai Liu, Hui Xu, Peng Wu, Mingying Gui, Weijie Qu. Autophagy promotes α-amanitin-induced apoptosis of Hepa1-6 liver cells. Chemical research in toxicology, 10.1021/acs.chemrestox.1c00297. 2022
[2] Xiaolong Gu, Feiyan Dai, Xiao Xiao, GuanZhong Li, Limei Zhang, Weijie Qu. Effect of Ageratina adenophora on hepatic and pulmonic pathological lesions in horses.Polish Journal of Veterinary Sciences, 24(4):611-613. doi: 10.24425/pjvs.2021.139987. 2021
[3] Xiaolong Gu, Tariq Ali,Rongrong Chen, Guoliang Hu, Yu Zhuang, Junrong Luo, Huabin Cao, Bo Han. In vivo studies of molybdenum-induced apoptosis in kidney cells of caprine. Biological Trace Element Research, 165(1):51-58. 2015
[4] Xiaolong Gu, Rongrong Chen, Guoliang Hu, Yu Zhuang, Junrong Luo, Caiying Zhang, Xiaoquan Guo, Aiming Huang, Huabin Cao. Cell apoptosis of caprine spleen induced by toxicity of cadmium with different levels of molybdenum. Environmental Toxicology and Pharmacology, 40(1):49-56. doi: 10.1016/j.etap.2015.05.001. 2015
[5] Xiaolong Gu, Dandan Han, Wei Chen, Limei Zhang, Qianyun Lin, Jian Gao, Séamus Fanning, Bo Han. SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride. Oncotarget, 4; 7(40): 65218-65230. 2016
[6] Xiaolong Gu, Wiebke Albrecht, Karolina Edlund, Franziska Kappenberg, Jörg Rahnenfuehrer, Marcel Leist, Wolfgang Moritz, Patricio Godoy, Cristina Cadenas, Rosemarie Marchan, Tim Brecklinghaus, Laia Tolosa Pardo, José V. Castell, Iain Gardner, Bo Han, Jan G. Hengstler, Regina Stoeber. Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes. Achieves of Toxicology, 92(12):3505-3515. 2018
[7] Qingyang Xiao#, Caiying Zhang#, Xiaolong Gu#,Yu Zhuang, Junrong Luo, Ping Liu, Xiaoquan Guo, Guoliang Hu, Huabin Cao. Varying dietary levels of molybdenum inducing cell apoptosis of spleen under cadmium stress in caprine.Biological Trace Element Research, 172(1):127-33.doi: 10.1007/s12011-015-0565-3. 2016
[8] Xiaolong Gu, Zhi Wang, Jian Gao, Dandan Han, Limei Zhang, Peng Chen, Guangjian Luo, Bo Han. SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride. Toxicology In Vitro,7; 57: 28-38. 2019
[9] Wiebke Albrecht#, Franziska Kappenberg#, Tim Brecklinghaus#, Regina Stoeber, Rosemarie Marchan, Mian Zhang, Kristina Ebbert, Hendrik Kirschner, Marianna Grinberg, Marcel Leist, Wolfgang Moritz, Cristina Cadenas, Ahmed Ghallab, Jörg Reinders, Nachiket Vartak, Christoph van Thriel, Klaus Golka, Laia Tolosa, José V Castell, Georg Damm, Daniel Seehofer, Alfonso Lampen, Albert Braeuning, Thorsten Buhrke, Anne-Cathrin Behr, Axel Oberemm, Xiaolong Gu, Naim Kittana, Bob van de Water, Reinhard Kreiling, Susann Fayyaz, Leon van Aerts, Bård Smedsrød, Heidrun Ellinger-Ziegelbauer, Thomas Steger-Hartmann, Ursula Gundert-Remy, Anja Zeigerer, Anett Ullrich, Dieter Runge, Serene M L Lee, Tobias S Schiergens, Lars Kuepfer, Alejandro Aguayo-Orozco, Agapios Sachinidis, Karolina Edlund, Iain Gardner*, Jörg Rahnenführer*, Jan G Hengstler*. Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Archives of Toxicology, 93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. 2019
[10] Dandan Han, Xiaolong Gu, Jian Gao, Zhi Wang, Gang Liu, Herman W. Barkema, Bo Han. Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. Free Radical Biology and Medicine, 137:1-12. (pii: S0891-5849(19)30139-X.) 2019
[11] Dandan Han, Lili Jiang, Xiaolong Gu,Shimeng Huang, Jiaman Pang, Yujun Wu, Jingdong Yin, Junjun Wang. SIRT3 Deficiency Is Resistant to Autophagy-Dependent Ferroptosis by Inhibiting the AMPK/mTOR Pathway and Promoting GPX4 Levels. Journal of Cell Physiology. doi: 10.1002/jcp.29727. 2020
[12] Dandan Han, Wei Chen, Xiaolong Gu, Ruixue Shan, Jiaqi Zou, Gang Liu, Muhammad Shahid, Jian Gao, Bo Han. Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Oncotarget, 28;8(9):14680-14692. 2017
[13] Dandan Han, Jian Gao, Xiaolong Gu, Jan Georg Hengstler, Limei Zhang, Muhammad Shahid, Tariq Ali, Bo Han. P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway. Achieves of Toxicology, 92(2):679-692.doi: 10.1007/s00204-017-2070-2. 2018.
[14]Muhammad Shahid, Jianfang Wang, Xiaolong Gu, Wei Chen, Tariq Ali, Jian Gao, Dandan Han, Rui Yang, Séamus Fanning, Bo Han. Prototheca zopfii induced ultrastructural features associated with apoptosis in bovine mammary epithelial cells. Frontiers in Cellular and Infection Microbiology, 13;7:299. doi: 10.3389/fcimb.2017.00299. 2017
[15] 顾小龙，王琦，曹华斌，张彩英，庄煜，胡国良，郭小权，黄爱民．钼对镉胁迫下山羊红细胞膜抗氧化功能和肝XOD基因转录的影响．畜牧兽医学报，45（10）：1726-1732．2014.
[16] 顾小龙，王琦，曹华斌，庄煜，张彩英，胡国良，郭小权，黄爱民．钼对镉胁迫下山羊红细胞膜自由基代谢及脾脏组织病理学的影响．中国兽医学报，34（9）：1527-1533．2014.
[17] 张立梅，刘影波，曲伟杰，郑勤琴，顾小龙．细菌操纵宿主细胞自噬的研究进展．中国病原生物学杂志，2019，14（07）：860-863．
[18] 张立梅，郑勤琴，曲伟杰，刘影波，顾小龙．内质网自噬的研究进展．生理科学进展，2020，51（01）：41-46．
[19] 许慧，王菊玉，张立梅，刘凯，邓健明，杨博文，曲伟杰，顾小龙，王生奎．槲皮素对小鼠肝肾慢性镉中毒保护作用的研究．中国兽医杂志，2022.
Words for students
In the new era,Chinese youth are in the best period for the development of the Chinese nation.We are confronted to the rare opportunity of making great achievements as well as the time mission of "the day will drop responsibilities on the man". We can be successful only after conquering trials and tribulations.