Name：Gefen Ying
Professional title：professor
Research focus：Animal viral Molecular epidemiology
Tutor category：RPhD Supervisor £Master Supervisor £Neither
E-mail address：761408466@qq.com
Education
2001-09 to 2004-06, People's Liberation Army Munitions University, Institute of Viral Diseases, Preventive Veterinary Medicine, D.Sc
1998-09 to 2001-06, Yunnan Agricultural University, College of Animal Science and technology, Preventive Veterinary Medicine, MAgr
1989-09 to 1993-06, Yunnan Agricultural University, Department of Husbandry and Veterinary, veterinarian, BAgr
Career
2017-07 to present, Yunnan Agricultural University, College of Veterinary Medicine, Professor
2012-10 to 2017-06, Yunnan Agricultural University, College of Animal Science and technology, Professor
2005-10 to 2012-09, Yunnan Agricultural University, College of Animal Science and technology, Associate professor
1996-10 to 2005-09, Yunnan Agricultural University, College of Animal Science and technology, Lecturer
1993-1 to 1996-09, Yunnan Agricultural University, College of Animal Science and technology, TA
Courses
Animal infectious diseases
Research focus
Prevention and control of animal infectious diseases, mechanism of virus infection and anti-infection, Animal viral Molecular epidemiology
Research & Teaching
Research projects
1. National Natural Science Foundation of China, 31560705, RACK1 regulates NF-kB signaling pathway in pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV) infection, 2016.01 to 2019.12, concluded, chairing
2.Key projects of basic research in Yunnan Province, 2016FA018, The role and mechanism of RACK1 regulating NF-kB signal pathway in the pathogenesis of csfv infection, 2016 to 2019, concluded, chairing
3. National Natural Science Foundation of China, 31960701, Role of RACK1 in regulation of ERK1/2 signaling pathway in porcine reproductive and respiratory syndrome virus infection and its molecular mechanism, 2020-01 to 2023-01-12, RMB 400,000, in progress, chairing
4. National Natural Science Foundation of China, 32360873, LOC103222771 negatively regulates the role and molecular mechanism of Claudin-4 in the pathogenesis of porcine reproductive and respiratory syndrome virus (PRRSV) infection, 2024-01 to 2027.RMB 123,200, in progress, chairing
5. Institute of Military Veterinary Medicine, Academy of Military Sciences, Horizontal cooperation projects, 2022Y30013, Protective evaluation of inactivated foot-and-mouth disease vaccine, 2022-12 to 2024. RMB 122,980, in progress, chairing
6. The Science and Technology Agency of Yunnan Province, Major Science and technology projects in Yunnan Province, 202002AE090020, Construction and application of technical system for prevention and control of important swine diseases in Yunnan province, 2021-06 to 2024-06，RMB 1,050,000, in progress, chairing
7. People's Liberation Army 1129 engineering office, Horizontal cooperation projects, KX132020021, Immune Evaluation and challenge protection of foot-and-mouth disease vaccine, 2018.09 to 2020.07, RMB 3,600,000, concluded, chairing
Teaching projects
1. Animal epidemiology, Key training project of Political Education Demonstration Course in universities of Yunnan Province, 2020.12 to 2022.12, concluded, chairing
Awards & Honors
1. Gefen Ying(1/20); Key technological innovations and applications for the prevention and control of major pig diseases, Second Prize of the National Agricultural and Livestock Fisheries Harvest Award for Achievement, 2019(Gefen Ying; Liangyu Yang; Junlong Bi; Xin Tao; Chunlian Song; Wanghua Zheng; Lingyun Zhu; Guishu Yang; Xiang Lee; Lei Wang; Xiaolao Huang; Qian Zhao; Xiao Liu; Guanxiong Chen; Yuan Yang; Zhijun Hong; Yonghua Lee; Guoming Yang; Yongtao Cao; Ling Zhang) (Research Award)
2．Gefen Ying(1/7); Research and application of key techniques for prevention and control of porcine reproductive and respiratory syndrome, The Government of the People's Republic of China of Yunnan Province, Progress in science and technology, other, 2019(Gefen Ying; Junlong Bi; Yuehu Wang; Chunlin Long; Yongxian Cheng; Xianghua Shu; Guishu Yang) (Research Award)
Representative achievements
Journal Publications
1.Bi, J., Zhao, Q., Zhu, L., Li, X., Yang, G., Liu, J., Yin, G., 2018. RACK1 is indispensable for porcine reproductive and respiratory syndrome virus replication and NF-kappaB activation in Marc-145 cells. Sci Rep 8, 2985.
2. Zhu, L., Bi, J., Zheng, L., Zhao, Q., Shu, X., Guo, G., Liu, J., Yang, G., Liu, J., Yin, G., 2018. In vitro inhibition of porcine reproductive and respiratory syndrome virus replication by shortantisense oligonucleotides with locked nucleic acid modification. BMC Vet Res 14, 109.
3.Liu, X., Bi, J., Zhao, Q., Li, M., Zuo, Q., Wang, X., Lan, R., Li, X., Yang, G., Liu, J., Yin, G., 2019. Overexpression of RACK1 enhanced the replication of porcine reproductive and respiratory syndrome virus in Marc-145 cells and promoted the NF-kappaB activation via upregulating the expression and phosphorylation of TRAF2. Gene 709, 75-83.
4. Yang, C., Lan, R., Wang, X., Zhao, Q., Li, X., Bi, J., Wang, J., Yang, G., Lin, Y., Liu, J., Yin, G., 2020. Integrin beta3, a RACK1 interacting protein, is critical for porcine reproductive and respiratory syndrome virus infection and NF-kappaB activation in Marc-145 cells. Virus Res 282, 197956.
5.Liu, X., Gao, L., Zhao, Q., Wang, X., Yang, C., Bi, J., Yang, R., Jin, X., Lan, R., Cui, R., Wang, X., Li, W., Wang, X., Yang, Y., Yu, X., Lin, Y., Liu, J., Yin, G., 2020. Inhibition of porcine reproductive and respiratory syndrome virus by PKC inhibitor dequalinium chloride in vitro. Vet Microbiol 251, 108913.
6.Yang, C., Zuo, Q., Liu, X., Zhao, Q., Pu, H., Gao, L., Zhao, L., Guo, Z., Lin, Y., Liu, J., Bi, J., Yin, G., 2021a. Small molecule screening identified cepharanthine as an inhibitor of porcinereproductive and respiratory syndrome virus infection in vitro by suppressing integrins/ILK/RACK1/PKCalpha/NF-kappaB signalling axis. Vet Microbiol 255, 109016.
Published books
Patents
1. Gefen Ying, Yongxian Cheng, Junlong Bi, Qing lyu, Guishu Yang, Xiang Lee, Application of atractylosin alcohol in pharmacy, ZL 2011 1 0263143.8
2. Gefen Ying, Yongxian Cheng, Junlong Bi, Qing lyu, Guishu Yang, Xiang Lee, Application of ethoxysanguinarine in pharmaceutical industry, ZL 2011 1 0263379.1
3. Gefen Ying, Junlong Bi, Wengui Lee, Xiang Lee, Longlong Zheng, Guishu Yang, Antisense DNA sequence for the treatment and prevention of porcine reproductive and respiratory syndrome and its application, ZL 2014 1 0445817.X
Words for students
As heaven maintains vigor through movements, a gentleman should constantly strive for self-perfection; as earth's condition is receptive devotion, a gentleman should hold the outer world with broad mind.