Name：Hong-Ye Zhao
Professional title：Professor
Research focus：Basic Veterinary Medicine
Tutor category：RPhD Supervisor RMaster Supervisor £Neither
E-mail address：hyzhao2000@126.com
Education
1992/9-1996/7 Yunnan Agricultural University Agriculture Bachelor
1996/9-1999/7 South China Agricultural University Agriculture Master
2002/4-2004/3 Kagoshima University Agriculture Master
2004/3-2008/6 Kagoshima University Doctor of Philosophy in Medical Science
Career
2008/11-2009/3, Institute of Health Sciences, Tokushima Bunri University, Guest Researcher
2009/10-2010/8, National Center for Biodiversity Research, Yunnan Agricultural University, Lecturer
2010/8-2021/12, National Center for Biodiversity Research, Yunnan Agricultural University, Professor
2022/1- present, College of Veterinary Medicine, Yunnan Agricultural University, Professor
Courses
1. Laboratory Animal Science
2. Animal Welfare
3. Animal Welfare and Ethics
4. Scientific Research Integrity and Academic Morality
5. Animal Reproductive Bioengineering
6. Cellular Molecular Biology
Research focus
1. Creation of Gene edited miniature pig model for Major Human Diseases
2. Construction of Immune Humanized Pig Model
3. Research on the Mechanism of New Use of Old Anticancer Drugs
Representative achievements
I mainly carry out research on the creation of pig models for human diseases, the construction of immune humanized gene editing pig models, and the mechanisms of new use of old anti-cancer drugs. presided two projects funded by the National Natural Science Foundation of China, and have signed over 20 cooperation project contracts with universities, research institutes, and enterprises such as Jiangxi Agricultural University, Zhejiang University Binjiang Research Institute, and Hangzhou Qihan Biotechnology Co., Ltd. Published over 60 academic papers in internationally renowned journals such as Science, Nature Biomedical Engineering, Cancer research, etc; Won one first prize in Yunnan Province's Technology Invention Award and establish one local standard formulation as the second finisher; obtained one authorized invention patent as the first inventor, four authorized invention patents and one utility model patent as a participating inventor.
Representative Publications
[1] Kaixiang Xu#, Honghao Yu#, Shuhan Chen#, Yaxuan Zhang#, Jianxiong Guo, Chang Yang, Deling Jiao, Tien Dat Nguyen, Heng Zhao, Jiaoxiang Wang, Taiyun Wei, Honghui Li, Baoyu Jia, Muhammad Ameen Jamal, Hong-Ye Zhao*, Xingxu Huang*, Hong-Jiang Wei*. Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation. Frontiers in Veterinary Science. 2022. 9:848833.
[2] Kaixiang Xu#, Wanyun Zhu#, Anyong Xu#, Zhe Xiong, Di Zou, Heng Zhao, Deling Jiao, Yubo Qing, Muhammad Ameen Jamal, Hong-Jiang Wei*, Hong-Ye Zhao* . Inhibition of FOXO1‑mediated autophagy promotes paclitaxel‑induced apoptosis of MDA‑MB‑231 cells. Molecular Medicine Reports. 2021, 1. 25(2):72. doi: 10.3892/mmr.2022.12588.
[3] Honghui Li#, Wenmin Cheng#, Bowei Chen#, Shaoxia Pu, Ninglin Fan, Xiaolin Zhang, Deling Jiao, Dejia Shi, Jianxiong Guo, Zhuo Li, Yubo Qing, Baoyu Jia, Hong-Ye Zhao*, Hong-Jiang Wei*. Efficient Generation of P53 Biallelic Mutations in Diannan Miniature Pigs Using RNA-Guided Base Editing. Life (Basel). 2021, 11(12):1417. DOI: 10.3390/life11121417.
[4] Yubo Qing#, Muhammad Ameen Jamal#, Dejia Shi#, Sumei Zhao, Kaixiang Xu, Deling Jiao, Heng Zhao, Honghui Li, Baoyu Jia, Haizhen Wang, Hong-Ye Zhao* , Hong-Jiang Wei*. Delayed body development with reduced triglycerides levels in leptin transgenic pigs. Transgenic Research. 2021, DOI: 10.1007/s11248-021-00288-1.
[5] Luhan Yang, George Church, Hong-Ye Zhao, Lusheng Huang, Yangbin Gao, Hong-Jiang Wei, Geoffrey Yang. Porcine germline genome engineering. Proceedings of the National Academy of Sciences of the United States of America. 2021, 118(22): e2004836117. DOI: 10.1073/pnas.2004836117. (IF=11.201)
[6] Yanan Yue#, Weihong Xu#, Yinan Kan#, Hong-Ye Zhao#, Yixuan Zhou, Xiaobin Song, Jiajia Wu, Juan Xiong, Dharmendra Goswami, Meng Yang, Lydia Lamriben, Mengyuan Xu, Qi Zhang, Yu Luo, Jianxiong Guo, Shengyi Mao, Deling Jiao, Tien Dat Nguyen, Zhuo Li, Jacob V. Layer, Mailin Li, Violette Paragas, Michele E. Youd, Zhongquan Sun, Yuan Ding, Weilin Wang, Hongwei Dou, Lingling Song, Xueqiong Wang, Lei Le, Xin Fang, Haydy George, Ranjith Anand, Shi Yun Wang, William F. Westlin, Marc Güell, James Markmann, Wenning Qin, Yangbin Gao, Hong-Jiang Wei*, George M. Church*, Luhan Yang*. Extensive germline genome engineering in pigs. Nature Biomedical Engineering. 2020, 5(2):134-143 DOI: 10.1038/s41551-020-00613-9. (IF=18.952)
[7] Honghao Yu#, Weihu Long#, Xuezeng Zhang#, Kaixiang Xu, Jiangxiong Guo, Heng Zhao, Honghui Li, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Xingxu Huang* and Hong-Jiang Wei*. Generation of GHR-modified pigs as Laron syndrome models via a dual-sgRNAs/Cas9 system and somatic cell nuclear transfer. Journal of translational medicine. 2018, 16:41. (IF=4.197)
[8] Yongfeng Shen#, Kaixiang Xu#, Zaimei Yuan, Jiangxiong Guo, Heng Zhao, Xuezeng Zhang, Lu Zhao, Yubo Qing, Honghui Li, Weirong Pan, Baoyu Jia, Hong-Ye Zhao*, Wei Hong-Jiang*. Efficient generation of P53 biallelic knockout Diannan miniature pigs via TALENs and somatic cell nuclear transfer. Journal of translational medicine. 2017, 15:224-234. (IF=4.197)
[9] Chaoxiang Lv#, Hao Qu#, Wanyun Zhu, Kaixiang Xu, Anyong Xu, Baoyu Jia, Yubo Qing, Honghui Li, Hong-Jiang Wei*, Hong-Ye Zhao*. Low-Dose Paclitaxel Inhibits Tumor Cell Growth by Regulating Glutaminolysis in Colorectal Carcinoma Cells. Frontiers in Pharmacology. 2017, 8:244. (IF=4.481)
[10] Hong-Ye Zhao, Ooyama A, Yamanoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Zhang S, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M,Akiyama S. Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU. Cancer research. 2008, 68(17): 7035-7041. (IF=9.329)
[11] Hong-Ye Zhao, Ooyama, A, Yamamoto M, Ikeda R, Haraguchi M, Tabata S, Furukawa T, Che XF, Iwashita K, Oka T, Fukushima M, Nakagawa M, Ono M, Kuwano M, Akiyama S. Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells. Cancer letters. 2008, 270(1):156-163. (IF=5.621)
[12] Junchen Chen , Weiqi Zeng , Weirong Pan , Cong Peng, Jianglin Zhang, Juan Su, Weihu Long, Heng Zhao, Xiaoxia Zuo, Xiaoyun Xie, Jing Wu, Ling Nie, Hong-Ye Zhao, Hong-Jiang Wei , Xiang Chen. Symptoms of systemic lupus erythematosus are diagnosed in leptin transgenic pigs. PLoS Biol. 2018, 16(8): e2005354. (IF= 9.163)
[13] Dong Niu *, Hong-Jiang Wei *, Lin Lin*, Haydy George *, Tao Wang *, I-Hsiu Lee *, Hong-Ye Zhao, Yong Wang, Yinan Kan, Ellen Shrock, Emal Lesha, Gang Wang, Yonglun Luo, Yubo Qing, Deling, Jiao, Heng Zhao, Xiaoyang Zhou, Shouqi Wang, Hong Wei, Marc Guell, George M. Church and Luhan Yang. Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9. Science. 2017, 357:1303-1307. (IF= 41.058)
[14] Honghao Yu#, Heng Zhao#, Yubo Qing, Weirong Pan, Baoyu Jia, Hong-Ye Zhao, Xingxu Huang*, Hong-Jiang Wei*. Porcine zygote injection with Cas9/sgRNA Results in DMD-modified pig with muscle dystrophy. International journal of molecular sciences. 2016, 17: 1668. (IF=3.257)
[15] Ooyama A, Oka T, Hong-Ye Zhao, Yamamoto M, Akiyama S, Fukushima M. Anti-angiogenic effect of 5-fluorouracil-based drugs against human colon cancer xenografts. Cancer letter. 2008, 267(1): 26-36. (IF=5.621)