姓名：顾小龙
职务：科研秘书，研究生第一党支部书记
职称：副教授
学科：临床兽医学
导师类别：硕士生导师
电子邮箱：xuewu24588@126.com
教育经历
2013.09-2018.06，中国农业大学，动物医学院，临床兽医学，农学博士
2016.09-2018.02，德国莱布尼兹工作环境与人为因素研究中心，毒理学部，系统毒理学
2010.09-2013.06，江西农业大学，动物科学与技术学院，临床兽医学，农学硕士
2006.09-2010.06，江西农业大学，生物科学与工程学院，生物工程，工学学士
工作经历
2021.10-至今， 云南农业大学畜牧学博士后科研流动站，博士后
2020.10-至今， 云南农业大学，动物医学院，副教授（破格）
2019.07-2021.05，楚雄州姚安县前场镇木署村，驻村工作队员
2018.09-2020.09，云南农业大学，动物医学院，未定级
所授课程
1. 兽医临床诊断学
2. 兽医内科学
3. 兽医专业英语
4. 动物福利概论
研究领域与方向
1. 动物营养代谢与中毒病
2. 肝脏药理与毒理学
科研与教学
科研项目
1.国家自然科学基金委，国家自然科学基金青年项目，NO. 31902335，PP2A-Akt/Beclin 1信号路径在α-鹅膏毒肽诱导的小鼠肝细胞自噬中的作用，2020.01-2022.12，24万元，已结题，主持
2.云南省科技厅，云南省基础研究专项-青年项目，NO. 202001AU070097，Nrf2/HO-1信号路径在镉诱导的小鼠肾细胞焦亡中的作用，2020.10-2023.09，5万元，已结题，主持
3.国家自然科学基金委，国家重点研发计划，NO. 2016YFD0501203，微量元素及维生素对奶牛乳房炎防控作用的研究子课题：牛羊微量元素、维生素和电解质失衡防控技术研究，2016.07-2020.10，67.5万元，已结题，参与
4.云南省人力资源和社会保障厅，兴滇英才后续项目经费支持，PINK1-Parkin信号路径介导的线粒体自噬在α-鹅膏毒肽致肝损伤中的作用机制，2023.01-2027.12，85万元，在研，主持
5.云南省人力资源和社会保障厅，博士后定向资助经费，解淀粉芽孢杆菌通Nrf2/HO-1抑制AFB1诱导的小鼠肝细胞焦亡的研究，2023.01-2024.12，16万元，在研，主持
6.云南省科技厅，云南省农业联合专项重点项目，NO. 202301BD070001-017，TOMM与PINK1-Parkin互作介导的线粒体质量控制在α-鹅膏毒肽致肝损伤中的作用，2023.01-2025.12，50万元，在研，主持
7.云南省科技厅，云南省个旧市牛产业科技特派团，NO.202304BI090007，200万元，2023.01-2025.12，在研，参与
教学项目
无
学术荣誉与奖励
1.研究生第一党支部，云南农业大学党建工作样板党支部，云南农业大学，2023。
2.顾小龙，社会服务先进个人，优秀学业导师，云南农业大学，2022。
3.顾小龙，云南省高校优秀共产党员，云南省教育厅，2020。
4.顾小龙，云南省“千人计划”青年人才，云南省人力资源和社会保障厅，2019。
代表性成果
代表性文章
[1] Chao Sun, Fang Yang, Jian hui Xiao, Wenwen Zhou, Jun Li, Xiaolong Gu. Simulating ozone degradation of deoxynivalenol (DON) and its biosafety assessment by mouse model. Frontiers in Microbiology, 2023
[2] Juyu Wang, Jieyan Yang, Kai Liu, Weijie Qu, KuanWang, YuZhao, Yaxiong Zhou, XiangLiu, Limei Zhang,*, Xiaolong Gu,*. Quercetin protects cadmium-induced renal injuries in mice by inhibiting cell pyroptosis. Frontiers in Veterinary Science, 2023, 10:1319857. doi: 10.3389/fvets.2023.1319857
[3] Kuan Wang, Jinlong Cha, Kai Liu, Jianming Deng, Bowen Yang, Hui Xu, Juyu Wang, Limei Zhang, Xiaolong Gu, Cuiqin Huang, Weijie Qu. The prevalence of Staphylococcus aureus associated bovine mastitis in China and its antimicrobial resistance rate: a meta-analysis, Frontiers in Veterinary Science. doi: 10.3389/fvets.2022.1006676. 2022, 9:1006676.
[4] Xiaolong Gu,Limei Zhang,Weixing Sun,Kai Liu,Hui Xu, Peng Wu, Mingying Gui, Weijie Qu. Autophagy promotes α-amanitin-induced apoptosis of Hepa1-6 liver cells. Chemical research in toxicology, 10.1021/acs.chemrestox.1c00297. 2022
[5] Xiaolong Gu,Feiyan Dai,Xiao Xiao,GuanZhong Li,Limei Zhang,Weijie Qu. Effect of Ageratina adenophora on hepatic and pulmonic pathological lesions in horses.Polish Journal of Veterinary Sciences,24(4):611-613.doi: 10.24425/pjvs.2021.139987. 2021
[6] Xiaolong Gu,Tariq Ali,Rongrong Chen, Guoliang Hu,Yu Zhuang,Junrong Luo, Huabin Cao, Bo Han. In vivo studies of molybdenum-induced apoptosis in kidney cells of caprine. Biological Trace Element Research, 165(1):51-58. 2015
[7] Xiaolong Gu,Rongrong Chen, Guoliang Hu, Yu Zhuang,Junrong Luo, Caiying Zhang, Xiaoquan Guo, Aiming Huang, Huabin Cao. Cell apoptosis of caprine spleen induced by toxicity of cadmium with different levels of molybdenum. Environmental Toxicology and Pharmacology, 40(1):49-56. doi: 10.1016/j.etap.2015.05.001. 2015
[8] Xiaolong Gu,Dandan Han,Wei Chen,Limei Zhang,Qianyun Lin,Jian Gao, Séamus Fanning, Bo Han.SIRT1-mediated FoxOs pathways protect against apoptosis by promoting autophagy in osteoblast-like MC3T3-E1 cells exposed to sodium fluoride. Oncotarget, 4; 7(40): 65218-65230. 2016
[9]Xiaolong Gu,Wiebke Albrecht,Karolina Edlund,Franziska Kappenberg,Jörg Rahnenfuehrer, Marcel Leist,Wolfgang Moritz,Patricio Godoy,Cristina Cadenas, Rosemarie Marchan,Tim Brecklinghaus,Laia Tolosa Pardo,José V. Castell,Iain Gardner, Bo Han,Jan G. Hengstler, Regina Stoeber.Relevance of the incubation period in cytotoxicity testing with primary human hepatocytes.Achieves of Toxicology, 92(12):3505-3515. 2018
[10]Qingyang Xiao,Caiying Zhang,Xiaolong Gu (equal first authors ),Yu Zhuang, Junrong Luo, Ping Liu,Xiaoquan Guo, Guoliang Hu,Huabin Cao.Varying dietary levels of molybdenum inducing cell apoptosis of spleen under cadmium stress in caprine.Biological Trace Element Research,172(1):127-33. doi: 10.1007/s12011-015-0565-3. 2016
[11]Xiaolong Gu,Zhi Wang, Jian Gao,Dandan Han,Limei Zhang,Peng Chen, Guangjian Luo, Bo Han. SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride. Toxicology In Vitro, 7; 57: 28-38. 2019
[12]Wiebke Albrecht#, Franziska Kappenberg#, Tim Brecklinghaus#, Regina Stoeber, Rosemarie Marchan, Mian Zhang, Kristina Ebbert, Hendrik Kirschner, Marianna Grinberg, Marcel Leist, Wolfgang Moritz, Cristina Cadenas, Ahmed Ghallab, Jörg Reinders, Nachiket Vartak, Christoph van Thriel, Klaus Golka, Laia Tolosa, José V Castell, Georg Damm, Daniel Seehofer, Alfonso Lampen, Albert Braeuning, Thorsten Buhrke, Anne-Cathrin Behr, Axel Oberemm, Xiaolong Gu, Naim Kittana, Bob van de Water, Reinhard Kreiling, Susann Fayyaz, Leon van Aerts, Bård Smedsrød, Heidrun Ellinger-Ziegelbauer, Thomas Steger-Hartmann, Ursula Gundert-Remy, Anja Zeigerer, Anett Ullrich, Dieter Runge, Serene M L Lee, Tobias S Schiergens, Lars Kuepfer, Alejandro Aguayo-Orozco, Agapios Sachinidis, Karolina Edlund, Iain Gardner#, Jörg Rahnenführer#, Jan G Hengstler#. Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations. Archives of Toxicology, 93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. 2019
[13] Dandan Han, Xiaolong Gu, Jian Gao, Zhi Wang, Gang Liu, Herman W. Barkema, Bo Han.Chlorogenic acid promotes the Nrf2/HO-1 anti-oxidative pathway by activating p21Waf1/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells. Free Radical Biology and Medicine, 137:1-12. (pii: S0891-5849(19)30139-X.) 2019
[14] Dandan Han, Lili Jiang, Xiaolong Gu, Shimeng Huang, Jiaman Pang, Yujun Wu, Jingdong Yin, Junjun Wang. SIRT3 Deficiency Is Resistant to Autophagy-Dependent Ferroptosis by Inhibiting the AMPK/mTOR Pathway and Promoting GPX4 Levels. Journal of Cell Physiology. doi: 10.1002/jcp.29727. 2020
[15]Dandan Han, Wei Chen, Xiaolong Gu, Ruixue Shan, Jiaqi Zou, Gang Liu, Muhammad Shahid, Jian Gao, Bo Han. Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K/Akt-mediated Nrf2/HO-1 signaling pathway. Oncotarget, 28; 8(9):14680-14692. 2017
[16]Dandan Han, Jian Gao, Xiaolong Gu, Jan Georg Hengstler, Limei Zhang, Muhammad Shahid, Tariq Ali, Bo Han. P21Waf1/Cip1 depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2/HO-1 pathway. Achieves of Toxicology, 92(2):679-692. doi: 10.1007/s00204-017-2070-2. 2018.
[17] Muhammad Shahid, Jianfang Wang, Xiaolong Gu,Wei Chen, Tariq Ali, Jian Gao, Dandan Han, Rui Yang, Séamus Fanning, Bo Han. Prototheca zopfii induced ultrastructural features associated with apoptosis in bovine mammary epithelial cells. Frontiers in Cellular and Infection Microbiology, 13;7:299.doi: 10.3389/fcimb.2017.00299. 2017
[18] 顾小龙，王琦，曹华斌，张彩英，庄煜，胡国良，郭小权，黄爱民．钼对镉胁迫下山羊红细胞膜抗氧化功能和肝XOD基因转录的影响．畜牧兽医学报，45（10）：1726-1732．2014
[19] 顾小龙，王琦，曹华斌，庄煜，张彩英，胡国良，郭小权，黄爱民．钼对镉胁迫下山羊红细胞膜自由基代谢及脾脏组织病理学的影响．中国兽医学报，34（9）：1527-1533．2014
[20] 张立梅，刘影波，曲伟杰，郑勤琴，顾小龙．细菌操纵宿主细胞自噬的研究进展．中国病原生物学杂志，2019，14（07）：860-863．
[21] 张立梅，郑勤琴，曲伟杰，刘影波，顾小龙．内质网自噬的研究进展．生理科学进展，2020，51（01）：41-46．
[22] 许慧，王菊玉，张立梅，刘凯，邓健明，杨博文，曲伟杰，顾小龙，王生奎．槲皮素对小鼠肝肾慢性镉中毒保护作用的研究．中国兽医杂志，2023, 59(04):137-142．
写给学生的话
新时代中国青年处在中华民族发展的最好时期，既面临着难得的建功立业的人生际遇，也面临着“天将降大任于斯人”的时代使命。忍受磨炼，才能成功。
